Finally, to validate the role of RBFOX1 downregulation in mediating mRNA stability changes in human glioblastoma cells and to investigate whether restoring RBFOX1 activity can rescue the destabilization of its target transcripts, we overexpressed RBFOX1 in the human glioblastoma cell line A172 (Supplementary Fig. 6) and performed RNA-seq. This evidence concerns the gene RBFOX1 and glioblastoma.