CCS and cancer: Notably, we found that in general, cancers of gynaecological origin (Cervical squamous cell carcinoma and endocervical adenocarcinoma, CESC; Ovarian serous cystadenocarcinoma, OV; and Uterine Carcinosarcoma, UCS) display the highest BC-CCS levels and Head and Neck squamous cell carcinoma (HNSC), Kidney Chromophobe (KICH) and Kidney renal papillary cell carcinoma (KIRP) the lowest (Fig. 3b).