First, the retrogene product could be co-immunoprecipitated in CRC cells with a number of signaling molecules, including protein kinases such as MST1R, PRKCA, ERBB2 and several of its known interactors, as well as modulators of GTPase activation such as the RAS effector protein RIN1. The gene discussed is ERBB2; the disease is colorectal carcinoma.