This sequence was initially identified as a MYC enhancer, but evidence indicates that it also acts on the LTR66 integrant situated upstream, including i) a physical interaction between the two elements documented in several CRC cell lines25, ii) a concordance of their ATAC-seq profiles in CRC tumors from the TCGA cohort26, and iii) our functional data. This evidence concerns the gene MYC and colorectal carcinoma.