Accordingly, this locus was enriched in the activation marks H3K4me1 and H3K27ac in LS1034 and HT55, two CRC cell lines expressing the TcGT, but not in SW480, where LTR66-POU5F1B is not detected (Fig. 3c and Supplementary Fig. 1e). Here, POU5F1B is linked to colorectal carcinoma.