POU5F1B and hepatocellular carcinoma: Finally, the presence of POU5F1B-encoding TcGTs in several other malignancies, including breast, prostate, stomach, and uterus, the previous identification of the POU5F1B locus as an integration hotspot for human papillomavirus and the coincidence of its transcripts with more advanced histological grades in cervical cancer59,60, as well as the documentation of its amplification in some gastric tumors51 and growth-promoting effect on hepatocellular carcinoma cell lines50 all indicate that our findings have a relevance that likely extends well beyond colorectal cancer alone.