Importantly, POU5F1B-encoding TcGTs were expressed in both microsatellite stable (MSS) and microsatellite unstable (MSI) tumors, and in all four CRC consensus molecular subtypes (CMS)19 (Supplementary Fig. 1f), although they were found more frequently in the MSS and CMS2 subsets. The gene discussed is POU5F1B; the disease is colorectal carcinoma.