CMS2 tumors are characterized by marked WNT and MYC signaling activation19, and the MYC coding sequence is located some 300 kb downstream of POU5F1B. Yet, while there was a significant correlation between POU5F1B and MYC expression in CRC cell lines and tumor samples, the presence of many outliers indicated that the two genes were not systematically coregulated (Supplementary Fig. 1g). This evidence concerns the gene MYC and colorectal carcinoma.