POU5F1B and colorectal cancer: This led us to identify the aberrant TE-driven expression of POU5F1B, a hominid-restricted retrogene, as a strong negative predictor of the clinical course of this malignancy and to determine that its POU5F1B product is responsible for fostering the growth and metastatic potential of colorectal cancer cells through a combination of cis- and trans-effects.