Levels of SerpinA1, a serine protease inhibitor previously reported to promote CRC progression40, were increased in the presence of POU5F1B in both SW480 and LS1043 cells, as were those of ROCK2 and its target EZR, two kinases regulating cytoskeletal reorganization, cell adhesion, and cell motility41,42. The gene discussed is ROCK2; the disease is colorectal carcinoma.