In contrast, no association between age and the tau hub ratio was detected for asymptomatic patients with preclinical AD (ADNI: β = 0.087, p = 0.542, Fig. 2A, left panel; BioFINDER: β = −0.307, p = 0.901, Fig. 2B, left panel), in which abnormal tau-PET signal was minimal. This evidence concerns the gene MAPT and Alzheimer disease.