In patients with preclinical AD, we also found a significant association between a higher tau hub ratio at baseline and a faster subsequent tau accumulation rate in ADNI (β = 0.347, p = 0.006, Fig. 4D, left panel), controlling for sex and education, however this finding could not be replicated in BioFINDER (β = 0.199, p = 0.469, Fig. 4E, left panel). This evidence concerns the gene MAPT and Alzheimer disease.