Supporting this, we found that ApoE4-carriage was associated with a lower tau hub ratio in amyloid-positive (i.e., AD) patients (ADNI/BioFINDER: F = 4.816/4.404, Cohen’s d = 0.4/0.3, p = 0.036/0.038), while controlling for age, sex, education and diagnosis. The gene discussed is APOE; the disease is Alzheimer disease.