MAPT and Alzheimer disease: In line with previous work3,4, we found that younger age was associated with a faster annual change rate in global tau-PET positivity in patients with symptomatic AD (ADNI: β = −0.284, p = 0.009, Fig. 4B, right panel; BioFINDER: β = −0.836, p < 0.001, Fig. 4C, right panel), using linear regression controlling for sex, education and diagnosis.