MAPT and Alzheimer disease: To address these open questions, the major aims of the current combined tau-PET and resting-state fMRI study were to assess whether: (1) younger age is associated with stronger tau pathology in globally connected hub regions compared to non-hubs in patients with symptomatic AD; (2) whether tau pathology in hub regions is associated with accelerated subsequent tau spreading and; (3) whether the association between younger age and faster tau accumulation rates in symptomatic AD3 is mediated by stronger tau pathology in globally connected hub regions.