Supporting a role of hubs for cognition in AD, we found previously that higher global connectivity fronto-parietal control network hubs such as the left frontal cortex is associated with a more efficient (i.e., small-world) global brain network topology48 and attenuated effects of posterior-cingulate glucose hypometabolism25, hippocampal atrophy43,49,50 or entorhinal tau pathology on cognitive performance27. The gene discussed is MAPT; the disease is Alzheimer disease.