MAPT and Alzheimer disease: Supporting this, we found that younger age was indeed associated with stronger hub-ness (i.e., shorter connectivity-based distance to the rest of the brain) of tau epicenters in patients with symptomatic AD (ADNI: β = 0.300, p = 0 < 0.001, Fig. 2C, right panel; BioFINDER: β = 0.646, p < 0.001, Fig. 2D, right panel), using linear regression controlling for sex, education and diagnosis.