As expected, no association between younger age and faster tau accumulation was detected in patients with preclinical AD (ADNI: β = −0.119, p = 0.389, Fig. 4B, left panel; BioFINDER: β = 0.208, p = 0.448, Fig. 4C, left panel), suggesting that faster tau accumulation or tau accumulation in general at younger age is specific for subjects with symptomatic AD. Here, MAPT is linked to Alzheimer disease.