Using longitudinal cognitive data available in symptomatic AD patients of the ADNI sample, we could further show that faster annual tau accumulation was associated with a faster decline in a memory composite (i.e., ADNI-MEM, β = −0.322, p = 0.004, Fig. 5B, controlling for age, sex and education), suggesting that faster tau hub ratio-dependent accumulation of tau pathology may drive faster clinical deterioration in younger patients with clinical AD. Here, MAPT is linked to Alzheimer disease.