Research has revealed that before inflammation, necrosis, and fibrosis of cardiomyocytes in DMD patients, Purkinje fiber cells undergo changes due to dystrophin deletion, which provides important pathophysiological evidence that ECG may more sensitively reflect and/or detect early manifestations of myocardial involvement in DMD patients compared with echocardiography and even CMR imaging. The gene discussed is DMD; the disease is Duchenne muscular dystrophy.