CD8A and neoplasm: A recent study using laser capture microdissection gene expression profiles classified four different immune-tumor microenvironment (TME) subtypes42, including the “inflamed” subtype, characterized by CD8+ T cells distributed in both epithelial and stromal tumor compartments and high immune gene expression, compared with the less immune-activated margin and stroma restricted-TME subtypes, and the least immune-activated group, the “immune desert”, in which there were few CD8+ T cells at all, and only at the margin42.