SEMA6B and Insulin resistance: Genes commonly upregulated in the IR-iPSCs when compared to each IS-iPSC group include EGR1 and MFGE8, which were previously associated with insulin resistance [25–30], as well as CD74, SEMA6B, SLFN13, TMEM151B, SLC22A17, and AGRN (Fig. 3G–I).