To determine if tau hyperphosphorylation was affected by FTI treatment in an amyloid mouse model, immunoblot analysis was performed for phospho-tau at serine 404 (Fig. 1H; Fig. S3E), an epitope known to be hyperphosphorylated in AD brains and in 5XFAD mice [47, 49]. The gene discussed is MAPT; the disease is Alzheimer disease.