Additionally, chromatin immunoprecipitation (ChIP) assay revealed that MYBL1 bound to region 6: −585 to −219 within the ANGPT2 promoter region (Fig. 4F), indicating that MYBL1 transcriptionally upregulates ANGPT2 by targeting the ANGPT2 promoter in HCC. The gene discussed is ANGPT2; the disease is hepatocellular carcinoma.