Interestingly, in our study we found that MYBL1 was not only overexpression in HCC but also in other gastrointestinal malignancy (pancreatic cancer, esophageal carcinoma, stomach adenocarcinoma, colon cancer), and upregulation of MYBL1 induces angiogenesis promotes HCC cells metastasis. This evidence concerns the gene MYBL1 and carcinoma of esophagus.