Importantly, we found that the Ki67 positive ratio and the EV density, as indicated by the number of CD31-positive vessels, was significantly increased in HepG2/MYBL1 tumors, and decreased in HepG2/MYBL1-RNAi tumors (Fig. 3E), suggesting that MYBL1 contributes to HCC angiogenesis in vivo. This evidence concerns the gene MKI67 and hepatocellular carcinoma.