Furthermore, the MTHFD1 variant (rs1076991) minor T-allele has been associated with an approximately 62.5% drop-in transcription rate of the MTHFD1 enzyme, which could also be associated with intercellular SAM accumulation, conditions that lead to dyslipidaemia and the consequent increased CVD risk [16]. Here, MTHFD1 is linked to inherited lipid metabolism disorder.