TFF1 and nephrolithiasis: Although a strong correlation between rs3761376 and nephrolithiasis risk was observed, we didn’t explore the potential effect of rs3761376 on regulation of TFF1. Many previous researches indicated that TFF1 was an estrogen-induced protein and rs3761376 was capable of changing the motifs of specified transcription factors, especially estrogen receptor 1 (ESR1) [32, 42, 43].