This specificity is clearly mirrored in AD iNs, where the main necroptosis regulators MLKL and RIPK3 are barely detectable at the mRNA level, and no differences were observed between control and AD iNs; however, a more detailed protein analysis is required to evaluate the relative importance of different cell death pathways in AD neurons (Figure S6D). This evidence concerns the gene MLKL and Alzheimer disease.