Despite the fact that sporadic AD iNs displayed a hypo-mature state (Mertens et al., 2021) and that the UniProt term apoptosis was significantly enriched in the gene module ADM2, we did not observe considerable fractions of control or AD iNs positive for the apoptotic marker cleaved caspase-3 (Casp3) under standard culture conditions (Figures 6A and 6B). This evidence concerns the gene CASP3 and Alzheimer disease.