Cancer types selected for this trial included HCC and SCCHN, which are moderately immune-responsive to anti-PD-1/PD-L1 monotherapy, and GBM and EOC, which are immune-resistant cancers for which PD-1/PD-L1 axis blockade alone has not been shown to be effective. The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.