Among the drug-free patients, the ROC analysis of the combined values of pLG72 levels and the ΔCT values of SLC7A11 mRNA for AD patients vs healthy controls determined an optimal cutoff value (24.985) with a favorable sensitivity (0.907) and a modest specificity (0.777) (AUC = 0.915). This evidence concerns the gene SLC7A11 and Alzheimer disease.