A clinical study of women with a family history of treated allergic diseases receiving Limosilactobacillus reuteri ATCC 55730 during late pregnancy reported a modulation in DNA methylation of CD4 + T cells genes related to immune maturation and allergy development in infants at birth, suggesting that epigenetic modifications may mediate the preventative effects of probiotics in this context [85]. This evidence concerns the gene CD4 and allergic disease.