HOXA-AS3 expression was upregulated in several human disorders and pathophysiological processes, such as liver cancer, glioma, lung cancer, oral cancer, colorectal cancer, gastric cancer, pancreatic cancer, endometriosis, atherosclerosis, pulmonary arterial hypertension, and the osteogenic differentiation of MSCs. This evidence concerns the gene HOXA-AS3 and atherosclerosis.