CD27 and neoplasm: To provide further validation of our in vitro and ex vivo data showing that FLOT and CROSS CT treatment of OGJ tumours can significantly alter the CD27 and CD69 expression and the differentiation status of T cells, we profiled the activation status of T cells in the peripheral blood and tumour of a cohort of OGJ patients in the treatment-naïve, post-FLOT and post-CROSS CRT clinical setting (Fig. 5).