In comparison with the control group, PI3K inhibitors significantly increased the risk of pruritus and dry skin (RR 1.63, 95% CI 1.14–2.33, p = 0.007, Figure S3; RR 3.34, 95% CI 2.30–4.85, p < 0.00001, Figure S4). Here, PIK3CA is linked to Pruritus.