INS and Insulin resistance: Yet, in a number of mouse inbred strains, including mouse models of type 2 diabetes (T2D), when rapamycin is administered through the diet, it ameliorates multiple T2D‐driven impairments and either has no effect on insulin resistance, or actually promotes insulin sensitivity, even while exacerbating hyperglycemia (Lamming et al., 2013; Reifsnyder et al., 2014, 2016, 2018, 2020; Yang et al., 2012).