The RAPA‐ and RAPA/MET‐induced reduction in adipose tissue myeloid infiltration and expression of genes for inflammatory stress‐responsive factors and cell senescence (Itgam, Itgax, Hmox1, Lbp, and Serpine1) demonstrate that these treatments specifically suppress obesity‐associated inflammation (Figure 3c). Here, TRERF1 is linked to obesity due to melanocortin 4 receptor deficiency.