The RAPA‐induced effects on insulin‐sensitive hepatic gene expression (elevation of gluconeogenic G6pc and reduction of Ldlr expression) indicate that dietary rapamycin in a genetic context of T2D vulnerability, such as that for NcZ10 males, may promote mTORC2‐dependent hepatic insulin resistance as does i.p.‐ injected rapamycin (Lamming et al., 2012, 2014) in normoglycemic mice. This evidence concerns the gene INS and type 2 diabetes mellitus.