RAPA‐treatment reduced hepatic glucokinase (Gck) and increased glucose‐6‐phosphatase (G6pc) expression (Figure 4e, Table S2), which could reduce phosphorylation of intracellular free glucose and increase release of glucose into circulation (Iynedjian, 2009), contributing to the RAPA‐induced hyperglycemia through an mTORC2‐mediated mechanism (Lamming et al., 2014). Here, GCK is linked to Hyperglycemia.