This effect could be mediated by RAPA‐ and RAPA/MET suppression of genes for cytokines such as Hmox1 (heme oxygenase 1), Lbp (lipopolysaccharide binding protein), and Serpine1 (plasminogen activator inhibitor‐1, PAI‐1) in both fat depots (Figure 3b, Table S1), which are key genes for the production of signals that promote inflammatory chemotaxis, systemic inflammation, and insulin resistance (Alessi et al., 2007; De Taeye et al., 2005; Huang et al., 2012). This evidence concerns the gene HMOX1 and Insulin resistance.