Such a mechanism could also occur in the islet vessels and be enhanced by the HFD‐induced dyslipidemia and obesity, which are able to further impair the Akt/eNOS signaling (De Boer et al., 2012; Vecoli et al., 2014; Wang et al., 2006). The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.