Similarly, basal glycemia was significantly higher at both 8 and 16 weeks in HFD vs CF groups (8 wks: WT CF 140 ± 3.7; WT HFD 171 ± 8.0*; eNOS CF 156 ± 6.5; eNOS HFD 187 ± 5.9*§ mg/dl; 16 wks: WT CF 151 ± 2.8; WT HFD 183 ± 5.8*; eNOS CF 156 ± 3.8; eNOS HFD 192 ± 8.4*§ mg/dl; *p < 0.01 vs WT CF, §p < 0.05, at least, vs eNOS CF [post‐hoc Tukey test]). Here, NOS3 is linked to cystic fibrosis.