Animals with partial eNOS gene deletion (+/− heterozygote mice), a model which more closely mimics the effects of clinical eNOS gene polymorphisms, have coronary vascular dysfunction and develop hypertension and overt insulin resistance mainly when fed with a high‐fat diet (HFD) (Cook et al., 2004; Vecoli et al., 2014). The gene discussed is NOS3; the disease is Hypertension.