UPF1 and neoplasm: In addition, CCK8, EdU, wound healing, Transwell, angiogenesis, and tumorsphere assays, along with western blotting suggested that knocking down UPF1 could partially rescue the decrease in the tumor malignant behavior owing to SLERCC overexpression; conversely, overexpression of UPF1 partially inhibited the enhanced tumor malignant behaviors due to knocking down of SLERCC (Fig. 8D-K and Fig. S10A-D).