Subjects carrying a pathogenetic variant in SOS1 gene tend to exhibit a distinctive phenotype that is characterized by ectodermal abnormalities (keratosis, pilaris, hyperkeratocic skin, sparse eyebrows, sparse thin and curly scalp hairs) generally not associated with cognitive deficits in place of which mood disorders such as anxiety or depression have been described along with absence of growth impairment. This evidence concerns the gene SOS1 and keratosis.