WNT5A and neoplasm: Moreover, the upregulation of histone lysine demethylase 1 (LSD1) in myCAFs might inhibit IFN activation to evade immune attack.[79] The Wnt5a signaling protein produced by myCAFs might also suppress the immune response to facilitate tumor metastasis (Figure 6A).[80, 81] In summary, the myCAFs might be able to potentiate the TME and promote tumor progression.