Interestingly, survival analysis using POSTN alone showed that its high expression was significantly associated with poorer survival (Figure S6A–D, Supporting Information), whereas the expression level of ITGB4 failed to yield a significant difference in the survival of patients with CSCC (Figure S6E–H, Supporting Information), suggesting that POSTN could serve as a reliable molecular and functional indicator of myCAFs. Here, POSTN is linked to skin squamous cell carcinoma.