MECOM and cancer: These two modules were also associated with multiple signaling pathways linked with cancer, such as PI3K−Akt and PI3K−Akt−mTOR signaling pathway (Figure 4D, bottom).[70] Regulatory network analysis of myCAFs with GENIE3 revealed 1,242 regulatory pairs (Table S9, Supporting Information, weight > 0.05).[110] Among them, 11 transcription factors (TFs) targeting more than 30 genes (Figure 4E), which included ESR1, GLIS3, KLF5, MECOM, PRRX1, RORA, RUNX1, SOX5, TCF4, TFCP2L1,and TP63.