POSTN and skin squamous cell carcinoma: Intriguingly, the expression of POSTN was positively associated with KDR (also known as VEGFR, vascular endothelial growth factor receptor), which may enhance angiogenesis and induce immunosuppression during cancer metastasis.[86] We further used ImmuCellAI to predict the response to immunotherapy of 252 patients with CSCC from the TCGA database.[116] Only ten patients were predicted to be sensitive to immunotherapy, whereas the remaining 242 were resistant.