KRT5 and bacterial infectious disease: A study describes basal urothelial cells expressing Sonic Hedgehog (Shh) and Cytokeratin-5 (Ck5) in ShhCreER/WT and R26mTmG/WT mouse-derived organoids, which include pluripotent stem cells that are capable of self-renewing and regenerating all cell types within the urothelium in response to bacterial infection or chemical damage in the bladder [54].