In addition to the induction of neurogenesis and neuroprotection, MSCs-derived exosome was found to enable the recovery of PD by promoting intracellular adhesion molecule-1 (ICAM1)-mediated angiogenesis of human brain microvascular endothelial cells (HBMECs) in a mice model of PD [240]. The gene discussed is ICAM1; the disease is Parkinson disease.