ACE2 and hypertensive disorder: Moreover; without pre-existing systemic HTN; SARS-CoV induces down regulation of ACE2 in host cells, resulting in increased concentration of angiotensin II which in turn causes severe acute lung injury, also ACE2 has important role in regulation of rennin angiotensin system which is responsible for regulation of blood pressure, vascular resistance and fluid electrolyte balance [29].