Additionally, our observations reveal a molecular basis for the intercellular communication between EBV-positive NPC cells and the TME, with particular emphasis on the transmission of viral product-containing exosomes to primary fibroblasts, demonstrating that viral product-containing exosomes enhance the release of FAPα, activation of YAP1 signaling, fibrotic response, immune suppression, and tumor growth in NPC. This evidence concerns the gene FAP and nasopharyngeal carcinoma.