CAFs express fibroblast activation protein-alpha (FAPα), smooth muscle actin alpha (α-SMA), PDGF receptor alpha (PDGFRα), PDGF receptor beta (PDGFRβ), and/or fibroblast specific protein 1 (FSP-1/S100A4) [1, 2], depending on the type of cancer. This evidence concerns the gene S100A4 and cancer.