Furthermore, it has been reported that patients with systemic lupus erythematodes (SLE), Sjögren’s syndrome, RAG1 and RAG2 deficiency and X-linked immunodysregulation polyendocrinopathy enteropathy (IPEX) can generate type I IFN auto-antibodies [126–128]. This evidence concerns the gene RAG2 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.