Most recently, a TLR7 de novo missense variant, reported in a female patient with SLE, was shown to cause systemic B-cell-driven autoimmunity through enhanced TLR7 signalling with a break of central B cell tolerance and accumulation of CD11c+ age-associated B cells and germinal centre B cells in mice [100]. Here, TLR7 is linked to systemic lupus erythematosus.