Specific experiments were carried out to assess the altered immune response upon in vitro SARS-CoV-2 infection, showing that TLR3−/−, TLR3+/−, IRF7−/− and IFNAR1−/− fibroblasts had increased infection susceptibility and that plasmacytoid dendritic cells (pDC) from IRF7-deficient patients did not produce IFN-I after infection. The gene discussed is IRF7; the disease is infection.