Furthermore, in pan-ancestry whole-exome sequencing data of over 500,000 individuals from the UK biobank, including more than 20,000 patients who contracted COVID-19, the burden of rare variants in TLR7 was found to be significantly increased in patients with severe COVID-19 (OR 4.53 (2.64–7.77)) [50]. Here, TLR7 is linked to COVID-19.