A detailed functional study further elucidated that one of these variants, rs10774671(G>A), impaired C-terminal prenylation of the OAS1 isoforms that consequently do not efficiently detect SARS-CoV-2, while higher concentrations of circulating OAS1 and expression of prenylated OAS1 have been associated with protection from severe COVID-19 [40]. This evidence concerns the gene OAS1 and COVID-19.