Apoptosis was activated, and cell cycle arrest was seen in 786-O and 769-P cells treated with kaempferol discovered by Song et al. They found that this bioflavonoid inhibited the EGFR/p38 MAPK signaling pathways, increased p21, decreased cyclin B1, stimulated PARP cleavages, induced apoptosis, and inhibited cell proliferation in human renal cell carcinoma (RCC) cells [123]. Here, CCNB1 is linked to renal cell carcinoma.