In 2018, an investigation on IMR32 and Neuro2A cells (human and mouse neuroblastoma cell lines), showed this flavonol structure induced neuroblastoma differentiation, decreased cell viability, promoted apoptosis, modulated the IRE1α (inositol-requiring enzyme one alpha) expression, and activated the IRE1α endoribonuclease [104]. This evidence concerns the gene ERN1 and neuroblastoma.