Zhong et al. confirmed that the overall survival and tumor-free survival rate of HCC patients with high infiltration of CD4 and CD8 T lymphocytes were significantly higher than those in low infiltration group, and their multivariate analysis showed that high infiltration of CD4 and CD8 T lymphocytes was a protective factor for HCC tumor recurrence and prognosis [50]. The gene discussed is CD4; the disease is hepatocellular carcinoma.