To further explore the prognostic role of CMTM4 in HCC immunotherapy, we did IHC and bioinformatics analysis to detect the co-expression of CMTM4 and PD-L1 in HCC patients, and evaluate the prognostic significance and immune characteristics of CMTM4 and PD-L1 co-expression combined with CD4+ or CD8+ T cell infiltration. Here, CMTM4 is linked to hepatocellular carcinoma.