Interestingly, the Treg signature suppressive molecules [37], including EBI3, ITGAE, TIGIT, CTLA4, and PDCD1, were upregulated in DLBCL Tregs (Fig. 4B), in agreement with their increased in vitro suppressive function demonstrated by the previous experiments. The gene discussed is CTLA4; the disease is diffuse large B-cell lymphoma.