To the best of our knowledge, ours is the first study to report that Lkb1 was significantly upregulated in Tregs from DLBCL patients compared with that in the control group, and that the upregulation of Lkb1 plays an important role in the regulation of Treg function and the immune environment of DLBCL. Here, STK11 is linked to diffuse large B-cell lymphoma.