The IHC results showed that the tumor proliferative activity was diminished as shown by the cell proliferation marker ki-67, and the EMT capacity was inhibited as shown by the mesenchymal markers N-cadherin and Vimentin, and the epithelial marker E-cadherin in sh-circFIRRE-1 group, while these tumor characteristics were rescued by miRNA sponges (Fig. 8C, Fig. S11). Here, MKI67 is linked to neoplasm.