For example, lncRNA FOXC2-AS1 directly bound to FOXC2 mRNA and increased its expression to confer doxorubicin resistance in osteosarcoma [51], while lncRNA HOXD-AS1 mediated the recruitment of PRC2 to the HOXD3 promoter to significantly repress the transcription of the HOXD3 gene [52]. This evidence concerns the gene FOXC2 and osteosarcoma.