DKK1 and colorectal carcinoma: Also, relative mRNA levels of several Wnt downstream genes (including Wnt1, Wnt3a, Wnt5b, LGR5, AXIN2, and CCND1) were decreased, while the Wnt inhibitor protein DKK1 was enhanced in STEAP3-AS1-knockdown CRC cells (Fig. 6H).