Interestingly, cluster 4 in relapse is characterized by elevated exocytosis (Supplemental Fig. 6D) and increased expression of genes related to Tim-3-galectin-9 Secretory Pathway (e.g. ADGRL1, HAVCR2 and LGALS9) that protect AML cells against from the host immune system in an mTOR dependent manner [32] (Supplemental Fig. 6E), in particular from NK- and T-cell action. Here, HAVCR2 is linked to acute myeloid leukemia.