To date, numerous targeted-liposomal systems for the delivery of chemical drugs (e.g. cisplatin, oxaliplatin, lonidamine, indinavir, irinotecan), proteins/peptides (e.g. eptifibatide, growth factors such as VEGF, EGF, GDNF and VEGF), and nucleic acids (e.g. siRNA, plasmid DNA, miRNA) using targeting ligands such as RGD peptide, PTD (HIV) peptide, folic acid and transferrin, have been broadly used in the treatment of cancers, infectious diseases and neurodegenerative diseases [151]. Here, VEGFA is linked to neurodegenerative disease.