TRPM3 and myalgic encephalomeyelitis/chronic fatigue syndrome: Although the pathophysiology is still not completely clear, previous studies have reported ME/CFS as a potential channelopathy and demonstrated the importance of Transient Receptor Potential Melastatin 3 (TRPM3) channel dysfunction in natural killer (NK) cells from ME/CFS patients (Marshall-Gradisnik et al. 2016; Nguyen et al. 2017; Cabanas et al. 2018, 2019a).