In contrast, and as previously shown, in NK cells from ME/CFS patients, ionic currents in the presence of PregS were mostly resistant to ononetin (Fig. 2D-F), in comparison with HC patients (Fig. 3C, p < 0.0001), indicating significant loss of the TRPM3 ion channel function in ME/CFS patients. The gene discussed is TRPM3; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.