We have previously shown higher CSF concentrations of the immune-related proteins IL-8, MCP-1, and chitinase-3-like protein 1 (YKL-40/CHI3L1) in bipolar disorder compared with controls in the SBP-S cohort using other analytical methods (see Supplementary table 10 for a comparison between the methods and results of the present study and the previously published studies) [5, 40]. This evidence concerns the gene CXCL8 and bipolar disorder.