Of note, studies that explore targeted treatment as first-line therapy instead of chemotherapy are already ongoing, e.g. the PROOF study (NCT03773302) with infigratinib and the FIGHT-302 study with pemigatinib (NCT03656536) for iCCA patients with FGFR2 fusions. Here, FGFR2 is linked to infantile convulsions and choreoathetosis.