The most commonly altered genes (Fig. 1) in tumour tissues were BAP1 (23%), ARID1A (22%), FGFR2 (22%), IDH1 (22%), CDKN2A (15%), CDKN2B (14%), PIK3CA (14%), TP53 (11%), ATM (9%), IDH2 (9%), BRAF (7%), SMARCA4 (7%) and FGFR3 (5%). The gene discussed is IDH2; the disease is neoplasm.