Within the myeloid cell cluster, we found the CCR2+ subpopulation in expanders highly expressing the on/fast-off-IFN gene signature, consistent with our findings in the murine models of tumour-infiltrating inflammatory monocytes being the predominant source of type I IFN activity and IFNβ in particular (Fig. 5i, j, l and Supplementary Fig. 10). The gene discussed is IFNB1; the disease is neoplasm.