PTEN and benign prostatic hyperplasia: Interestingly, PTEN is well-known for its anti-tumor functions in several cancers, inhibiting cell proliferation, enhancing apoptosis, and suppressing the EMT of cancer cells [50, 51], indicating that PTEN might mediate the effects of METTL3 on epithelial cell proliferation, apoptosis, and EMT in BPH in an m6A modification-related manner.