As for cell EMT, E-cadherin protein contents were reduced, but N-cadherin and vimentin protein contents were elevated in TGF-β-stimulated BPH-1 cells (**P < 0.01); after knocking down METTL3, E-cadherin was elevated, but N-cadherin and vimentin were reduced (##P < 0.01; Fig. 3F). The gene discussed is CDH2; the disease is benign prostatic hyperplasia.