In BPH rats’ prostate, E-cadherin was reduced (**P < 0.01), but N-cadherin and vimentin were elevated (**P < 0.01); after knocking down METTL3, E-cadherin was partially increased, but N-cadherin and vimentin were decreased (##P < 0.01; Fig. 2A–C), suggesting that METTL3 knockdown attenuates the EMT in BPH rats. This evidence concerns the gene CDH2 and benign prostatic hyperplasia.