BPH rats were injected with Lv-sh-METTL3 and/or Lv-sh-PTEN and examined for the mRNA and protein expressions of METTL3 and PTEN in rats’ prostate; in BPH rats’ prostate, METTL3 mRNA and protein expressions were downregulated by sh-METTL3; while didn’t affect by sh-PTEN (Fig. 6A–C). The gene discussed is PTEN; the disease is benign prostatic hyperplasia.