Additional high expression of signatures involved in immune-checkpoint component and tumour immunity such as IDO1, IFN Gamma, PD-L1 and Tumour Inflammation Signature (TIS) as well as the genomic risk score were associated with High Ki672wk (OR 1·67–1·49, FDR<0·0001–0·0084, logistic regression). The gene discussed is CD274; the disease is neoplasm.