Figure 4 shows the molecular features of the clusters (C): C1, C2 and C3 were characterised by PR to AI (60/111, 54·1%) and high Ki672wk (82/111, 73·9%) and an enrichment of HER2-E subtype (79/111; 71·2%) and Luminal B tumours (21/111, 18·9%) (Supplementary Figure S4A). This evidence concerns the gene PGR and neoplasm.