Specifically, IL-2, a cytokine required for regulatory T cell expansion in malaria (28, 29), was increased compared with baseline at day 4 PI, and this pattern persisted through day 10 PI in basoIL-18R (−) mice, while basoIL-18R (+) mice showed an increase above baseline only at days 6 and 8 PI (Fig. 6A). This evidence concerns the gene IL2 and malaria.