Then, we reconfirmed the genes expression in an independent 28 glioma samples by qRT‐PCR, and the higher riskscore were founded in the WHO Grade IV (Figure 2D), IDH‐wild‐type subgroup (Figure 2E) and 1p19q intact subgroup (Figure 2F), which are consistent with results in TCGA and CGGA datasets. Here, IDH1 is linked to central nervous system cancer.