Consistently, a dramatic decrease (∼60%) in cell viability (red fluorescence signal) was observed in the HER2+ CRC MOSs co-cultured with anti-HER2 CAR-T cells versus a slight decrease (∼20%) of the red HER2+ fluorescence signal observed in the bulk organoid culture (Figure 4G). The gene discussed is ERBB2; the disease is colorectal carcinoma.