Although this early work did not investigate the expression of tissue residence markers in the infiltrating T cells, later studies found that CRC patients carrying DNA mismatch repair (MMR)‐deficient tumors display an intra‐tumoral increase of CD8+ T cells with a bona fide Trm phenotype (CD69+CD103+, also expressing PD1, FAS, HLA‐DR, CD38 and TIM3) [96]. The gene discussed is CD8A; the disease is colorectal carcinoma.