However, most of the targets up-regulated in Mir501-KO mice at the protein level showed no significant changes at the RNA level in our Mir501-KO mice and in previously reported miR-501-3p–overexpressing SK-N-SH cell lines (29), shedding light on important regulatory roles of miR-501-3p in posttranscriptional gene expression associated with synaptic dysfunction underlying schizophrenia. The gene discussed is MIR501; the disease is schizophrenia.