Notably, we observed that both schizophrenia-associated up-regulated DEGs reported in the PsychENCODE brain RNA-seq dataset (26 overlapping genes; P < 0.001 and OR = 4.6) (28) and schizophrenia-risk genes (7 overlapping genes; P = 0.001 and OR = 6.9) (35, 36) were significantly associated with miR-501-3p putative protein targets up-regulated in the Mir501-KO mouse brain (Fig. 8A). The gene discussed is MIR501; the disease is schizophrenia.