CLCN5 and schizophrenia: We also observed that two subthreshold GWAS single-nucleotide polymorphisms [rs13059327 (P = 1.18 × 10−3) and rs181726666 (P = 8.75 × 10−3)] located upstream of MIR501 (37) and two ultrarare protein-altering variants in its host CLCN5 gene (ENST0000376088; c.1049G>A and c.2248C>T) (50) were associated with schizophrenia.