GRM5 and schizophrenia: We then used multiple rigorous approaches to translating findings in patients with schizophrenia to an animal model of disease and delineated the epigenetic mechanism by which the loss of schizophrenia-associated down-regulated miR-501-3p in mice induced sociability, memory, and sensorimotor gating disruptions through mGluR5-mediated excitatory glutamatergic transmission enhancement, providing etiological implications for schizophrenia.