GRM5 and schizophrenia: Of seven overlapping genes, Grm5, encoding mGluR5, was the most highly ranked z score of seven DEPs (z score = 12.8 and P = 0.008) and also displayed schizophrenia-associated up-regulation in the PsychENCODE brain RNA-seq dataset (log2FC = 0.043 and P = 0.02) (28).