These results were further supported by the proteomic results showing that several well-known schizophrenia risk genes encoding the proteins mGluR5, Gabrb2, and Shank3, which are involved in modulating chemical synaptic transmission, transsynaptic signaling, and synaptic signaling pathways, were identified as targets of miR-501-3p and were altered in Mir501-KO mouse brains. The gene discussed is SHANK3; the disease is schizophrenia.