ESRRG and Familial prostate cancer: Consistent with previous work in prostate cancer cells (22), we found that ectopic expression of V5-ESRRG-WT in HEK293 cells induced p21 expression associated with hypophosphorylation (activation) of RB1, whereas knockdown of endogenous ESRRG resulted in depletion of p21 and hyperphosphorylation (inactivation) of RB1 (Fig. 4F).