Other low frequency actionable fusions namely, AGK-BRAF, FIP1L1-PDGFRA, FNDC3B-PIK3CA, RET-NCOA4, SND1-BRAF, TMEM178B-MET, TMEM178B-BRAF, KANK1-NTRK3, EIF3E-RSPO2 and PTPRK -RSPO3 have been previously reported as rare fusions in tumours of other type [1, 28–34]. This evidence concerns the gene RSPO3 and neoplasm.