AGTR1 and hypertensive disorder: Nutritional imbalances can be associated with an upregulated renin-angiotensin-aldosterone system (RAAS) leading to cardiorenal pathologies, including hypertension [2], in which altered mechanisms of Na+ handling in the kidney and the heart are important, together with modifications of type 1 and type 2 angiotensin II receptor (AT1R and AT2R) signaling [3].