Concerning possible interactions between the Ang II⇒AT1R and Ang II⇒AT2R axes in the pathogenesis of hypertension in RBD rats, the contrast between the total normalization of SBP with Losartan alone and the diminished effect of this drug after a single administration of Ang-(3–4) (Fig 7) also deserves special consideration. The gene discussed is ANG; the disease is hypertensive disorder.