PLOD1 and neoplasm: RTV (relative tumor volume) were 1.86-, 3.38- and 4.74-fold of TV0 at day 4, 8 and day 12 in LH + DDP group, which were significantly less than 3.12-, 6.83- and 12.11-fold in NS group (p < 0.05); and much less than 2.81-, 4.83- and 6.63-fold in DDP group and 2.34-, 4.94 and 8.57-fold in LH group respectively (Fig. 4B).